Prof. Oscar Lee’s research team has been studying on how physical properties of the microenvironments, including three-dimensional spherical spatial boundary conditions, substrate stiffness, and mechanical forces contribute to the regulation of MSC differentiation over the years. We have used biophotonic approaches, such as Surface Plasmon Resonance Biosensor and Raman Spectroscopy, to monitor the differentiation of stem cells in a label-free & real-time manner.
- Chu SY, Chou CH, Huang HD, Yen MH, Hong HC, Chao PH, Wang YH, Chen PY, Nian SX, Chen YR, Liou LY, Liu YC, Chen HM, Lin FM, Chang YT, Chen CC* & Lee OK*. Mar. 2019. Mechanical stretch induces hair regeneration through the alternative activation of macrophages. Nat Commun. [Accepted]
- Wu HH, Ho JH, Lee OK*. 2016. Detection of hepatic maturation by Raman spectroscopy in mesenchymal stromal cells undergoing hepatic differentiation. Stem Cell Res Ther 7(1):6.
- Yen MH, Wu YY, Liu YS, Rimando MG, Ho JH*, OK Lee*. 2016. Efficient generation of hepatic cells from mesenchymal stromal cells by an innovative bio-microfluidic cell culture device. Stem Cell Res Ther 7(1):120. (Cover Feature)
- Hsieh WT, Liu YS, Lee YH, Rimando MG, Lin KH, Lee OK*. Mar. 2016. Matrix dimensionality and stiffness cooperatively regulate osteogenesis of mesenchymal stromal cells. Acta Biomater 32:210-22.
- Liu YS, Liu YA, Huang CJ, Yen MH, Tseng CT, Chien S, Lee OK*. Nov. 2015. Mechanosensitive TRPM7 mediates shear stress and modulates osteogenic differentiation of mesenchymal stromal cells through Osterix pathway. Sci Rep 5:16522.
- Shih YV, Hwang YS, Phadke A, Kang H, Hwang N, Caro EJ, Nguyen S, Siu M, Theodoraki EA, Gianneschi N, Vecchio K, Chien S*, Lee OK*, Varghese S*. Jan. 2014. Calcium-phosphate bearing matrices induce osteogenic differentiation of stem cells through adenosine signaling. P Natl Acad Sci USA 111(3):990-995
- Kuo YC, Chang TH, Hsu WT, Zhou J, Lee HH, Ho JH*, Chien S*, Lee OK*. Feb. 2015. Oscillatory shear stress mediates directional reorganization of actin cytoskeleton and alters differentiation propensity of mesenchymal stem cells. Stem Cells 33(2):429-42
- Kuo SW, Lin HI, Ho JH, Shih YR, Chen HF, Yen TJ*, Lee OK*. 2012. Regulation of the fate of human mesenchymal stem cells by mechanical and stereo-topographical cues provided by silicon nanowires. Biomaterials 33(20):5013-5022
- Kuo YC, Ho JH, Yen TJ, Chen HF, Lee OK*. Jul. 2011. Development of a surface plasmon resonance biosensor for real-time detection of osteogenic differentiation in live mesenchymal stem cells. PLoS ONE 6(7):e22382