Associate Professor at the Department of Biomedical Engineering
The Biomaterials and Stem Cell Tissue Engineering Laboratory (BSCTEL) is dedicated to the development of novel biomaterials for assisting biological studies and enhancing clinical therapies. Specific research directions include:
Functional biomaterials for regenerative medicine:
- bio-functional polymeric biomaterial scaffolds for tissue engineering applications: biomimetic materials to present microenvironmental cues to guide cell/tissue development
- physically functional biomaterials for clinical applications: mechanically robust, injectable and stimuli-responsive materials
- nanomaterials for gene/drug delivery and molecular imaging/detection
Stem cell tissue engineering
- investigate the role of microenvironment cues including mechanical forces, cell-scaffold interactions and biochemical factors on cellular function, tissue structure and development
- explore the regulatory mechanisms of musculoskeletaltissue mineralization
- advance stem cell-based tissue engineering technologies for cartilage and other musculoskeletal tissues
- Zhou H, Liang C, Wei Z, Bai Y, Bhaduri SB, Webster TJ, *Bian L, *Yang L. “Injectable biomaterials for translational medicine.” Materials Today, in press.
- Chen X, Li R, Wong SHD, Wei K, et al., Xia J, Chen G, Li G, *Bian L. “Conformational manipulation of scale-up prepared single chain polymeric nanogels for multiscale regulation of cells.” Nature Communications, 2019; volume 10:2075.
- +Xu J, +Feng Q, +Lin S, Yuan W, Li R, Li J, Wei K, Chen X, Zhang K, Yang Y, Wu T, Wang B, Zhu M, Guo R, *Li G, *Bian L. “Injectable stem cell-laden supramolecular hydrogels enhance in situ osteochondral regeneration via the sustained co-delivery of hydrophilic and hydrophobic chondrogenic molecules.” Biomaterials, 2019; 210:51-61.
- Wei K, Chen X, Zhao P, Feng Q, Yang B, Li R, *Zhang Z, *Bian L. “Stretchable and bio-adhesive supramolecular hydrogels activated by a one-stone-two-bird post-gelation functionalization method.” ACS Appl. Mater. Interfaces, 2019; 11 (18):16328–16335. DOI: 10.1021/acsami.9b03029.
- +Kang H, +Yang B, Zhang K, Pan Q, Yuan W, Li G, *Bian L. “Immunoregulation of macrophages by dynamic ligand presentation via ligand-cation coordination.” Nature Communications, 2019; volume 10: 1696.
- +Zhang K, +Yuan W, Wei K, Yang B, Chen X, Li Z, *Zhang Z, *Bian L. “Highly dynamic nanocomposite hydrogels self-assembled by metal ion-ligand coordination.” Small, 2019; smll.201900242.
- +Feng Q, +Xu J, Zhang K, Yao H, Zheng N, Zheng L, Wang J, Wei K, Xiao X, *Qin L, *Bian L. “Dynamic and cell-infiltratable hydrogels as injectable carrier of therapeutic cells and drugs for treating challenging bone defects.” ACS Central Science, 2019; 5 (3):440–450.
- +Kang H, +Wong SHD, Pan Q, Li G, *Bian L. “Anisotropic ligand nanogeometry modulates the adhesion and polarization state of macrophages.” Nano Lett., 2019; 13;19(3):1963-1975.
- +Wong SHD, +Yin B, Lin S, Yang B, Li R, Feng F, Yang H, Zhang L, Yang Z, Li G, *Choi CH, *Bian L. “Anisotropic nanoscale presentation of cell adhesion ligand enhances the recruitment of diverse integrins in adhesion structures and mechanosensing-dependent differentiation of stem cells.” Advanced Functional Materials, Volume 29, Issue 8, 2019; adfm.201806822.
- +Kang H, +Zhang K, Jung HJ, Yang B, Chen X, Pan Q, Li R, Xu X, Li G, Dravid V, *Bian L. “In situ reversible heterodimeric nanoswitch controlled by metal ion-ligand coordination regulates the adhesion, release, and differentiation of stem cells.” Advanced Materials, 2018; 30(44), adma.201803591.