Associate Professor at the School of Biomedical Sciences
Office: (852) 3943 1229
Address: Room 409A, 4/F, Lo Kwee-Seong Integrated Biomedical Science Building, Area 39, CUHK
SBS Website: https://www2.sbs.cuhk.edu.hk/en-gb/people/academic-staff/prof-jiang-xiaohua
Prof. JIANG Cynthia Xiaohua graduated from School of Medicine, Shanghai JiaoTong University, and completed her internship and residency at RuiJin Hospital in Shanghai. She obtained her PhD degree in cell biology from the University of Hong Kong. Prof. Jiang undertook her postdoctoral training at the Department of Medicine, UCLA and worked on the role of protein kinase cascades in cancer development. After that, she joined the University of Southern California as a CIRM (California Institute for Regenerative Medicine) fellow and her research focused on cellular and molecular basis of Ewing sarcoma by using human embryonic stem cells as an innovative model. Currently, she is an Associate Professor at the School of Biomedical Sciences. Her main research interests are molecular regulation of stem cells, stem cell therapy in neurological diseases and modeling embryonic development and pediatric cancer using pluripotent stem cells. Prof. Jiang has published more than 80 peer-reviewed papers, including Nature Medicine, Cell Research, Cell Death and Differentiation, Stem Cells, Stem Cell Reports and Cancer Research.
- Molecular regulation of adult stem cells
- Stem cell therapy in neurological diseases
- Crosstalk between stem cells and microenvironment during aging and regeneration
- Disease modeling using pluripotent stem cells
- Yin C, Wen G, Liu C, Yang B, Lin S, Huang J, Zhao P, Wong SHD, Zhang K, Chen X, Li G, Jiang X, Huang J, Pu K, Wang L, Bian L#. “Organic Semiconducting Polymer Nanoparticles for Photoacoustic Labeling and Tracking of Stem Cells in the Second Near-Infrared Window”. ACS Nano, 2018; 12(12):12201-12211.
- Liu S, U KP, Tsang LL, Huang JW, Jiang X. “R-spodin2 enhances canonical Wnt signaling to maintain the stemness of glioblastoma cells.” Cancer Cell Int, 2018; 18:156.
- Yang FY, Chen R, Zhang X, Huang B, Tsang LL, Li X, Jiang X. “Preconditioning enhances the therapeutic effects of mesenchymal stem cells on colitis through PGE2-mediated T cell modulation.” Cell Transplant, 2018; 27(9):1352-1367.
- Li X, Fok KL, Guo J, Wang Y, Liu Z, Chen Z, Wang C, Ruan YC, Yu SS, Zhao H, Wu J, Jiang X#, Chan HC#. “Retinoic acid promotes stem cell differentiation and embryonic development by transcriptionally activating CFTR.” Biochim Biophys Acta Mol Cell Res, 2018; 1865(4):605-615.
- Chen K, Liu Q, Tsang LL, Ye Q, Chan HC, Sun Y, Jiang X. “Human MSCs promotes colorectal cancer epithelial-mesenchymal transition and progression via CCL5/beta-catenin/Slug pathway.” Cell Death Dis, 2017; 8(5):e2819.
- Chen R, Lee WY, Zhang XH, Zhang JT, Lin S, Xu LL, Huang B, Yang FY, Liu HL, Wang B, Tsang LL, Willaime-Morawek S, Li G, Chan HC, Jiang X. “Epigenetic modification of the CCL5/CCR1/ERK axis enhances glioma targeting in dedifferentiation-reprogrammed BMSCs.” Stem Cell Reports, 2017; 8(3):743-757.
- Liu Z, Guo J, Wang Y, Weng Z, Huang B, Yu MK, Zhang X, Yuan P, Zhao H, Chan WY, Jiang X#, Chan HC#. “CFTR-beta-catenin interaction regulates mouse embryonic stem cell differentiation and embryonic development.” Cell Death Differ, 2017; 24(1):98-110.
- Meng F, Xu L, Huang S, Liu Y, Hou Y, Wang K, Jiang X#, Li G#. “Small nuclear ribonucleoprotein polypeptide N (Sm51) promotes osteogenic differentiation of bone marrow mesenchymal stem cells by regulating Runx2.” Cell Tissue Res, 2016; 366(1):155-162.
- Zhang J, Weng Z, Tsang K, Tsang L, Chan HC, Jiang X. “MycN is critical for the maintenance of human embryonic stem cell-derived neural crest stem cells.” PLoS ONE, 2016: 11(1):e0148062.
- Rui Y, Xu L, Chen R, Zhang T, Lin S, Hou Y, Liu Y, Meng F, Liu Z, Ni M, Tsang KS, Yang F, Wang C, Chan HC, Jiang X#, Li G#. “Epigenetic memory gained by priming with osteogenic induction medium improves osteogenesis and other properties of mesenchymal stem cells.” Sci Rep, 2015; 5:11056.