This seminar was delivered by Prof. Hon Fai CHAN.

It has been demonstrated that mechanical forces play a crucial role in intestinal development by contributing to gut looping, vilification, and mucosal folding. In particular, mechanical strain generated from the differential growth rate of different tissue layers has been postulated to induce surface folding/ buckling. While mucosal folding is a ubiquitous phenomenon observed in many hollow or tubular human tissues/ organs, such as stomach and small intestine, recapitulating the process for tissue engineering has yet to be achieved. In this seminar, Prof. Chan discussed his recent work on developing a multilayer cell-laden biomaterial scaffold to recapitulate the folding process in the intestine and explore the mechanical effect on encapsulated cells in vitro and in vivo. He also introduced his latest work on developing biomaterial-based therapeutics for intestinal regenerative medicine.

 

To explore further on his scientific accomplishment or to join Chan Lab, please visit https://honfaichan.wixsite.com/chanlab-cuhk.