Prof. CHAN, Pui Barbara

Professor

Personal Information

Professor of the Institute for Tissue Engineering and Regenerative Medicine

Office: (852) 3943 9797
Email: bpchan@cuhk.edu.hk
Address: Room 622A, 6/F, Lo Kwee-Seong Integrated Biomedical Science Building, Area 39, CUHK
ORCID: 0000-0002-5350-1138
SBS Website: https://www2.sbs.cuhk.edu.hk/en-gb/people/academic-staff/prof-chan-pui-barbara

Research interests

  1. Tissue engineering and regenerative medicine
  2. Enabling technologies
  3. Biomaterials
  4. Complex organoid and tumoroids
  5. Cell niche engineering
  6. Mechanoregulation

Selected Publications

  1. Wang XN, Ou WJ, Feng D, Gao B, Chan BP* (2023) A Bio-Functional Wnt3a Gradient Microarray for Cell Niche Studies. Advanced Functional Materials, 33(33):2301941.
  2. Yang XX, Yip CH, Zhao SR, Ho YP, Chan BP* (2023) A bio-inspired nano-material recapitulating the composition, ultra-structure, and function of the glycosaminoglycan-rich extracellular matrix of nucleus pulposus. Biomaterials, 293:121991.
  3. Yip CH, Chen AD, Wong YH, Chan BP* (2022) Multiphoton microfabrication and micropatternining (MMM)-based screening of multiplex cell niche factors for phenotype maintenance – Bovine nucleus pulposus cell as an example. Biomaterials, 281:121367.
  4. Lam KL, Wong YH, Chew SY, Chan BP* (2021) Rac1-GTPase regulates compression-induced actin protrusions (CAPs) of mesenchymal stem cells in 3D collagen micro-tissues. Biomaterials, 274:120829.
  5. Wang XN, Gao B, Chan BP* (2021) Multiphoton microfabrication and micropatterning (MMM) – An all-in-one platform for engineering biomimetic soluble cell niches. Biomaterials, 269:120644.
  6. Li CW, Lau YT, Lam KL, Chan BP* (2020) Mechanically induced formation and maturation of 3D-matrix adhesions (3DMAs) in human mesenchymal stem cells. Biomaterials, 258:120292.
  7. Li YY, Lam KL, Chen AD, Zhang W, Chan BP* (2019) Collagen microencapsulation recapitulates mesenchymal condensation and potentiates chondrogenesis of human mesenchymal stem cells–A matrix-driven in vitro model of early skeletogenesis. Biomaterials, 213:119210.
  8. Huang N, Li CW, Chan BP* (2018) Multiphoton 3D Microprinting of Protein Micropatterns with Spatially Controlled Heterogeneity – A Platform for Single Cell Matrix Niche Studies. Advanced Biosystems, 2(8):1800053.
  9. Yeung P, Zhang W, Wang XN, Yan CH, Chan BP* (2018) A human osteoarthritis osteochondral organ culture model for cartilage tissue engineering. Biomaterials, 162:1–21.
  10. Ho FC, Zhang W, Li YY, Chan BP* (2015) Mechanoresponsive, omni-directional and local matrix-degrading actin protrusions in human mesenchymal stem cells microencapsulated in a 3D collagen matrix. Biomaterials, 53:392–405.
  11. Li YY, Choy TH, Ho FC, Chan BP* (2015) Scaffold composition affects cytoskeleton organization, cell-matrix interaction and the cellular fate of human mesenchymal stem cells upon chondrogenic differentiation. Biomaterials, 52:208–220.
  12. Chik TK, Chooi WH, Li YY, Ho FC, Cheng HW, Choy TH, Sze KY, Luk KKD, Cheung KMC, Chan BP* (2015) Bioengineering a multicomponent spinal motion segment construct-a 3d model for complex tissue engineering. Advanced Healthcare Materials, 4(1):99–112.
  13. Chan BP*, Ma JN, Xu JY, Li CW, Cheng JP, Cheng SH (2014) Femto-Second Laser-Based Free Writing of 3D Protein Microstructures and Micropatterns with Sub-Micrometer Features: A Study on Voxels, Porosity, and Cytocompatibility. Advanced Functional Materials, 24(3):277–294.
  14. Yuan MT, Yeung CW, Li YY, Diao HJ, Cheung KMC, Chan D, Cheah K, Chan BP* (2013) Effects of nucleus pulposus cell-derived acellular matrix on the differentiation of mesenchymal stem cells. Biomaterials, 34(16):3948–3961.
  15. Cheng HW, Luk KDK, Cheung KMC, Chan BP* (2011) In vitro generation of an osteochondral interface from mesenchymal stem cell-collagen microspheres. Biomaterials, 32(6):1526–1535.
  16. Lee M, Lo AC, Cheung PT, Wong D, Chan BP* (2009) Drug carrier systems based on collagen-alginate composite structures for improving the performance of GDNF-secreting HEK293 cells. Biomaterials, 30(6):1214–1221.
  17. Chan OCM, So KF, Chan BP* (2008) Fabrication of nano-fibrous collagen microspheres for protein delivery and effects of photochemical crosslinking on release kinetics. Journal of Controlled Release, 129(2):135–143.
  18. Hui TY, Cheung KMC, Cheung WL, Chan D, Chan BP* (2008) In vitro chondrogenic differentiation of human mesenchymal stem cells in collagen microspheres: Influence of cell seeding density and collagen concentration. Biomaterials, 29(22):3201–3212.
  19. Wong HL, Wang MX, Cheung PT, Yao KM, Chan BP* (2007) A 3D collagen microsphere culture system for GDNF-secreting HEK293 cells with enhanced protein productivity. Biomaterials, 28(35):5369–5380.
  20. Chan BP*, Hui TY, Yeung CW, Li J, Mo I, Chan GCF (2007) Self-assembled collagen-human mesenchymal stem cell microspheres for regenerative medicine. Biomaterials, 28(31):4652–4666.