Personal Information

Assistant Professor at the School of Life Sciences

Office: (852) 3943 5021
Address: Rm 503B, Mong Man Wai Building, CUHK

Research Interests

  1. Vascular and metabolic biology
  2. Stem cell biology
  3. Cardiovascular regeneration

Selected Publications

  1. Ma S, Tian XY, Zhang Y, Mu C, Shen H, Bismuth J, Pownall HJ, Huang Y, Wong WT. “E-selectin-targeting delivery of microRNAs by microparticles ameliorates endothelial inflammation and atherosclerosis.” Sci Rep, 2016; 9(6):22910.
  2. Sayed N, Wong WT*, Ospino F, Meng S, Lee J, Jha A, Dexheimer P, Aronow B, Cooke JP. “Transdifferentiation of Human Fibroblasts to Endothelial Cells: Role of Innate Immunity.” Circulation, 2015; 131(3):300-9. *Co-first author.
  3. Cooke JP, Sayed N, Lee J, Wong WT. “Innate immunity and epigenetic plasticity in cellular reprogramming.” Current Opinion in Genetics & Development, 2014; 28:89-91.
  4. Wong WT, Huang NF, Botham CM, Sayed N, Cooke JP (2012). Endothelial cells derived from nuclear reprogramming. Circ Res. 111(10):1363-75.
  5. Tian XY, Wong WT*, Wang NP, Lu Y, Cheang WS, Liu J, Liu L, Liu Y, Lee SS, Chen ZY, Cooke JP, Yao X, Huang Y. “PPARδ activation protects endothelial function in diabetic mice.” Diabetes, 2012; 61(12):3285-93. *Co-first author.
  6. Tian XY, Wong WT*, Xu A, Lu Y, Zhang Y, Wang L, Cheang WS, Wang Y, Yao X, Huang Y. “Uncoupling Protein-2 Protects Endothelial Function in Diet-Induced Obese Mice.” Circ Res, 2012; 110(9):1211-6. *Co-first author.
  7. Tian XY, Wong WT*#, Wang YX, Leung FP, Ng CF, Lee HK, Yao X, Au CL, Lau CW, Vanhoutte PM, Cooke JP, Huang Y. “ROS-stimulated production of cyclooxygenase-2-derived prostaglandin F2a cause endothelial dysfunction and impaired renal blood flow in renovascular hypertensive rats.” Antioxid Redox Signal, 2012; 16(4):363-73. #Co-corresponding author.
  8. Wong WT, Tian XY, Xu A, Yu J, Lau CW, Hoo RL, Wang Y, Lee VWY, Lam KS, Vanhoutte PM, Huang Y. “Adiponectin is required for PPARγ-mediated improvement of endothelial function in diabetic mice.” Cell Metab, 2011; 6; 14(1):104-15.
  9. Wong WT#, Tian XY*, Chen YC, Leung FP, Liu LM, Lee HK, Ng CF, Xu A, Yao X, Vanhoutte PM, Tipoe GL, Huang Y. “Bone morphogenic protein-4 impairs endothelial function through oxidative stress-dependent cyclooxygenase-2 upregulation: Implications on hypertension.” Circ Res, 2010; 107(8):984-91. #Co-corresponding author
  10. Wong WT, Tian XY, Xu A, Ng CF, Lee HK, Chen ZY, Au, CL, Yao X, Huang Y. “Angiotensin II type 1 receptor-dependent oxidative stress mediates endothelial dysfunction in diabetic mice.” Antioxid Redox Signal, 2010; 13(6):757-68.