Mechanically-graded biomaterial for bone-tendon repair. (B) Bone-like and (C) tendon-like tissue patterning on mechanically-graded biomaterial in vivo. Tri, trichrome.
With the combined use of macroscale biomechanical (material stiffness) and biochemical cues (growth factor biopatterning), Prof. Michelle Wang’s group has developed a novel, bio-functionalized, mechanically-graded biomaterial that holds promise for hard-to-soft tissue regeneration such as rotator cuff repair.
- Ker DFE*, Wang D*, Behn AW, Wang ETH, Zhang X, Zhou BY, Mercado-Pagan AE, Kim S, Kleimeyer J, Gharaibeh B, Shanjani Y, Nelson D, Safran M, Cheung E, Campbell P, Yang YP. Functionally-Graded, Bone- and Tendon-Like Polyurethane for Rotator Cuff Repair. Advanced Functional Materials. 2018, 28(20): 1707107. *Co-first authors.
- Wang D, Xu Y, Lu C, Yang X, Zhang D, Shao L, Wang R. Comparison of fracture strength and fracture modes of zirconia dental ceramics manufactured by four different CAD/CAM systems. Key Engineering Materials. 2012, 492:30-34.